Phytoestrogens and magic herbs

[Tinker D]

I did, long time ago.
Made me a little bitchy.

As a mater of fact, I think I still have a TG formula I got way back in the early 2000. I’ll see if I dig it out.

[Like Ra]

Saw Palmetto (Serenoa repens) is a bit different thing. SP is supposed to contain an inhibitor of 5-alpha-reductase, an enzyme that converts testosterone to dihydrotestosterone (DHT), which might cause scalp temporal recession and pattern hair loss, excessive facial, axillary, pubic, and body hair growth, and prostate hyperplasia and prostate cancer risk. In adults, that is, because during the puberty it's responsible for, for example, development of male genitalia.

Some researches show, that SP might be efficient, so, apparently, results are individual. Finasteride, which is 18,000 times more potent, than Saw palmetto, is proved effective against alopecia 1mg) and benign prostate hyperplasia - BPH (5mg). In most EU countries, you need a doctor prescription to get finasteride, so, Saw palmetto can be an interesting alternative (or wasted money 😆).

And some other researches claim, that saw palmetto is no more effective, than placebo.

My goals are:
- stimulate scalp hair growth
- reduce body hair
- do something good for the prostate

It might take 4-6 months, though, to get to any conclusions...

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https://pubmed.ncbi.nlm.nih.gov/33313047/

Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia

Abstract

Saw palmetto (SP), a botanical extract with antiandrogenic properties, has gained commercial popularity for its purported benefits on hair regrowth. To summarize published evidence on the efficacy, safety, and tolerability of supplements containing SP in the treatment of alopecia, we conducted a PubMed, Google Scholar, and Cochrane database search using the following terms: (saw palmetto and hair loss), (saw palmetto and androgenetic alopecia), and (saw palmetto and natural supplement and alopecia). Five randomized clinical trials (RCTs) and 2 prospective cohort studies demonstrated positive effects of topical and oral supplements containing SP (100-320 mg) among patients with androgenetic alopecia (AGA) and telogen effluvium. Sixty percent improvement in overall hair quality, 27% improvement in total haircount, increased hair density in 83.3% of patients, and stabilized disease progression among 52% were noted with use of various topical and oral SP-containing supplements. SP was well tolerated and not associated with serious adverse events in alopecia patients. Although robust high-quality data are lacking, supplements containing SP may be a treatment option for patients with AGA, telogen effluvium, and self-perceived hair thinning. Further large-scale RCTs focusing on the sole contribution of SP to hair growth outcomes are needed to confirm efficacy and determine long-term adverse events.

[Like Ra]

O! Look at that: Aguaje Extract Pueraria Mirifica Maca Saw Palmetto Red Clover Wild Yam

This listing is for capsules of pure & high quality standardized extracts of :

Aguaje Fruit 10:1 Extract
blended with Pueraria Mirifica 10:1 Extract,
Maca Root Extract 12:1,
Saw Palmetto Berry Extract, 50% Fatty Acids & Sterols,
Red Clover Extract , 20% Isoflavones,
Wild Yam Root 10:1 Extract containing Diosgenine,
Fenugreek Seed Extract , 50% Saponins,
Fennel Seed 10:1 Extract,
Dong Quai Root 20:1 Extract containing 1% Ligustilide, 0.1% - 0.3% Ferulic Acid
Rosehip Extract, 25% Anthocyanidins,
Dandelion Extract 10:1,
Soy Isoflavone Extract 40% soy isoflavones.

eBay: Aguaje Extract Pueraria Mirifica Maca Saw Palmetto

Something to try? 😉

[dustymoon1]

Saw Palmetto (Serenoa repens) .

Saw Palmetto is used to treat enlarged prostate glands, not cancerous ones, just enlarged, which happens as we age.

[Like Ra]

Saw Palmetto is used to treat enlarged prostate glands, not cancerous ones, just enlarged, which happens as we age.

Yes, hence, BHP (benign prostate hyperplasia).

[neofinetia]

The effects of drugs are not independent of each other. Some will work together and some will be antagonistic. When the effect of one drug is not good enough, people will use multiple drugs together to try to achieve the effect they want. For example, the essential oils used in aromatherapy in spas are a variety of essential oils that are mixed in different proportions to produce different effects. This also avoids the irritation of sensitive skin by a single high-concentration essential oil. In the East, there are also Chinese medicines made from different herbs used to treat diseases. So why don't you consider combining medications? You can even buy a hamster or rabbit for observation, if allowed. (Do you have animal protection laws there?）

[Like Ra]

You can even buy a hamster or rabbit for observation

Fortunately, we have scientists/researches for that.

[neofinetia]

If you have your own laboratory, then the rest is the luck part, just like Edison found tungsten wire to make light bulbs.

[Like Ra]

Aguaje Fruit

Aguaje is a new name for me (no pun intended, yet 😬). It's marketed as a curve booster for crossdressers and transgenders.

Be a woman! Have a curvier butt, and bigger breasts the all natural way! Known for its high amount of phytoestrogens (all natural plant estrogens), the Aguaje Fruit is used to enhance the hips, buttocks and breasts naturally.
. . .
Men can also benefit nutritionally from consuming this fruit or using the oil as a way to moisturize and protect the skin, but the potential benefits for women are even more incredible. This is because Aguaje is rich in female hormonal phytoestrogens. Research on phytoestrogens is ongoing, but consumption of Aguaje doesn't seem to have any harmful effects on men. The phytoestrogens can provide almost certain benefits for women. The fruit can potentially restore fertility. It can be a great natural treatment for symptoms of menopause, and it can potentially increase breast size (women with higher levels of estrogen tend to be a bit curvier). For this reason, the female hormonal rich Aguaje powder is also growing in popularity in the respected LGBTQI community. Furthermore, its antioxidants can slow down the effects of aging on the skin by reducing wrinkles and fine lines.

As a side effect, just like Pueraria, Aguaje causes weight gain.

https://www.herbazest.com/news/aguaje-es...d-by-study

https://onlinelibrary.wiley.com/doi/10.1111/jfbc.13583
https://doi.org/10.1111/jfbc.13583

Estrogenic and antiandrogenic activities of methoxyflavans isolated from the fruit of Mauritia Flexuosa (Moriche Palm)


Abstract

Moriche palm is consumed as both a fresh fruit and processed food in Peru and Brazil. Although its fruit contains phytoestrogens, the active compounds have not yet been identified. Therefore, we purified moriche palm extract (MPE) and identified compounds exhibiting estrogenic and antiandrogenic activities. Estrogenic activity was assessed by the estrogen-dependent growth of MCF-7 cells and increases in uterine weights in mice. Antiandrogenic activity was evaluated by 5α-reductase inhibitory activity and prostate-specific antigen (PSA) expression in LNCaP cells. In vivo antiestrogenic activity was also assessed based on testosterone-induced prostate growth in castrated mice. Four methoxyflavans were isolated from MPE and all, except for 7,4′-dihydroxy-5-methoxyflavan, promoted MCF-7 cell growth, indicating estrogenic activity. Uterine and ovary weights increased in mice orally administered MPE (400 mg/kg) for 2 weeks. Regarding antiandrogenic activity, among the four methoxyflavans isolated, 6,7,4'-trihydroxy-5-methoxyflavan (1 µg/ml) suppressed the mRNA and protein expression of PSA in LNCaP cells. Furthermore, prostate growth was suppressed in mice orally administered MPE (200 mg/kg) for 2 weeks. All methoxyflavans inhibited 5α-reductase activity with IC50 less than 10 µg/ml. Collectively, the present results demonstrated that orally administered MPE exhibited estrogenic and antiandrogenic activities. Methoxyflavans, particularly 6,7,4′-trihydroxy-5-methoxyflavan, appear to be the active compounds for these activities.
Practical applications

The fruit of Mauritia flexuosa (moriche palm) has been used for beverages and processed foods. Although it is said to contain phytoestrogens, the active compounds have not yet been identified. In this study, we isolated and identified methoxyflavans exhibiting estrogenic and antiandrogenic activities. Among them, 6,7,4′-trihydroxy-5-methoxyflavan appeared to be the most effective compounds for these activities.

[FatalGRL]

I just ordered some of the pueraria stuff on a whim, with no real research or forethought. If I don't immediately forget then I'll try to take it for a couple of weeks to see what happens. If it's just an increase in sensitivity, Cool. If it's more then that, Less cool but it was my choice so whatever. I'll post an update once it's here, I s'pose.