(11 Aug 2025, 14:41 )Like Ra Wrote:(11 Aug 2025, 00:18 )Iniga Wrote: What I have often read & heard (thus the quotes), they can block the receptors supposedly.I think what you mean is related to the "growing technique" which involves periods of not taking any estrogens, to make the receptors vacant again.
Nope, different things.... I do agree with the "periods of not taking any estrogens" & do that, but more like a menstrual cycle as cis women experience it. If I don't take breaks, the influence seems (not scientifically, but felt) to be weaker to me. Again, I am not an endocrinologist, and no one should take what I say as medical advice or anything more than what I have found works best for me. Questions should be directed to an endocrinologist.
That read was fascinating but I did struggle with many parts of it.
My non endocrinological brain chose the word "attraction", the document you linked uses the word "affinity" which I assume is the correct one. If phytoestrogens attach to the receptors (either before or simply because they are able to, perhaps even preferred), less estradiol/E2 can (be the real estradiol source via HRT or produced by the body, which amab people also produce to a lower degree than most afab people).
I was kind of surprised that NIH doc did not fall prey to the recent transgender document purge... it mentions tests with transgenic mice/rats (i.e. genetically modified to mirror human responses)... which the current POTUS still believes and repeats often has something to do with non-existent mad scientist "transgender mice" (well who knows, maybe they do exist in nature, but we can't talk to them to find out). I was surprised there was *no* mention of M2F trans women on HRT.... *many* of those theories & questions could be much better answered by studying the effects on amab people who are on HRT... yet not a single mention.... Welcome to the Discworld..
Ironically, not studying the effects on amab people who are on HRT, is very much to the detriment of cis males with a prostate condition....
