(16 Sep 2025, 21:59 )Zooy Wrote: how are they putting 500mg on/in such a patch

Quote:In this study, we evaluate a few parameters and generally found a comparable effect in the control of pain, inflammation and oxidative stress between classical TCM Xiaotong patch and NSAIDs flurbiprofen patch, in a relatively short-term evaluation for treating EKOA.

(17 Sep 2025, 01:34 )Like Ra Wrote: Saying that, I also bought (oral) pills with extracts of Reishi, Lion's Mane, Black Cohosh, Saw Palmetto, and some others.

I like experiments  😅

(17 Sep 2025, 08:27 )Zooy Wrote: if you use too many things at the same time, you have no idea which is the one that is responsible for what of several effects.

Quote:We have previously found that licorice can reduce serum testosterone in healthy men. These results were not confirmed in another study, where the same amounts of licorice did not decrease salivary testosterone values. In the actual study we treated more cases with the same amount of licorice and reproduced our previous data. The mean testosterone values decreased by 26 % after one week of treatment (p < 0.01). There was also a significant increase in 17-OHP and LH concentrations and a slight, but not significant decrease in free testosterone. Licorice treatment, in addition, did not affect the response of testosterone and 17-OHP to stimulation with b-HCG.

Quote:serum testosterone concentrations were lowered only in the Paeonia lactiflora group
Serum 17β-estradiol concentrations were higher in the Paeonia lactiflora group
Aromatase converts androgens into estrogen in scalp hair follicles. The increase in estrogen in the experiment promotes hair growth.

Paeoniflorin, albiflorin, penta-O-galloyl-β-d-glucose, and other ingredients of PL have anti-oxidant, anti-inflammatory, anti-viral, and anti-tumor activities. Polysaccharides in PC extract have been shown to possess potent anti-tumor and anti-apoptotic activities and immune regulatory, hypoglycemic, anti-inflammatory, and anti-oxidant effects.

Interestingly, in the present study, PL significantly reduced serum testosterone and elevated 17β-estradiol levels, reduced the mRNA expressions of pro-inflammatory cytokines (TNF-α and IL-6), and lowered NR3C2 levels in the AGA-PL group than in the AGA-PC group (p < 0.05). Thus, PL more effectively inhibited pro-inflammatory cytokines [44]. We also found that AGA-Con reduced the PPARG expression and the other treatment groups raised the expression of PPARG. The potentiation of Akt and GSK-3β phosphorylation improved Wnt signaling to protect against hair loss induced by testosterone. Finasteride provides a recognized treatment for AGA [6,41,45] and has also been used to treat prostate cancer [46]. We demonstrated that finasteride had no apparent effect on hair growth during the early stage of the experiment, but that subsequently, it quickly promoted hair growth.